diff --git a/samples/drivers/uart/async_api/sample.yaml b/samples/drivers/uart/async_api/sample.yaml
index 4fc5566a84e..442bf777d65 100644
--- a/samples/drivers/uart/async_api/sample.yaml
+++ b/samples/drivers/uart/async_api/sample.yaml
@@ -9,5 +9,17 @@ tests:
       - uart
     filter: CONFIG_SERIAL and
             CONFIG_UART_ASYNC_API and
-            dt_chosen_enabled("zephyr,shell-uart")
+            dt_chosen_enabled("zephyr,shell-uart") and
+            not CONFIG_UART_MCUX_LPUART
+    harness: keyboard
+  sample.drivers.uart.async_api.lpuart:
+    tags:
+      - serial
+      - uart
+    filter: CONFIG_SERIAL and
+            CONFIG_UART_ASYNC_API and
+            dt_chosen_enabled("zephyr,shell-uart") and
+            CONFIG_UART_MCUX_LPUART and
+            not CONFIG_CPU_HAS_DCACHE
+    depends_on: dma
     harness: keyboard