diff --git a/drivers/entropy/Kconfig.nrf5 b/drivers/entropy/Kconfig.nrf5
index 37f6b0e8d49..91f0243c98e 100644
--- a/drivers/entropy/Kconfig.nrf5
+++ b/drivers/entropy/Kconfig.nrf5
@@ -16,6 +16,7 @@ menuconfig ENTROPY_NRF5_RNG
 	default y
 	depends on !ENTROPY_NRF_FORCE_ALT
 	depends on DT_HAS_NORDIC_NRF_RNG_ENABLED
+	depends on MULTITHREADING # k_sem_xxx() functions used in the driver
 	select ENTROPY_HAS_DRIVER
 	help
 	  This option enables the RNG peripheral, which is a random number