diff --git a/drivers/i2c/i2c_mcux_lpi2c_rtio.c b/drivers/i2c/i2c_mcux_lpi2c_rtio.c
index 07936da06c0..9c2eb106fe7 100644
--- a/drivers/i2c/i2c_mcux_lpi2c_rtio.c
+++ b/drivers/i2c/i2c_mcux_lpi2c_rtio.c
@@ -16,6 +16,9 @@
 #include <zephyr/kernel.h>
 #include <zephyr/irq.h>
 #include <fsl_lpi2c.h>
+#if CONFIG_NXP_LP_FLEXCOMM
+#include <zephyr/drivers/mfd/nxp_lp_flexcomm.h>
+#endif
 
 #include <zephyr/drivers/pinctrl.h>
 
@@ -40,6 +43,9 @@ LOG_MODULE_REGISTER(mcux_lpi2c);
 
 struct mcux_lpi2c_config {
 	DEVICE_MMIO_NAMED_ROM(reg_base);
+#ifdef CONFIG_NXP_LP_FLEXCOMM
+	const struct device *parent_dev;
+#endif
 	const struct device *clock_dev;
 	clock_control_subsys_t clock_subsys;
 	void (*irq_config_func)(const struct device *dev);
@@ -329,7 +335,15 @@ static int mcux_lpi2c_init(const struct device *dev)
 		return error;
 	}
 
+#if CONFIG_NXP_LP_FLEXCOMM
+	/* When using LP Flexcomm driver, register the interrupt handler
+	 * so we receive notification from the LP Flexcomm interrupt handler.
+	 */
+	nxp_lp_flexcomm_setirqhandler(config->parent_dev, dev,
+				      LP_FLEXCOMM_PERIPH_LPI2C, mcux_lpi2c_isr);
+#else
 	config->irq_config_func(dev);
+#endif
 
 	i2c_rtio_init(data->ctx, dev);
 
@@ -363,6 +377,13 @@ static DEVICE_API(i2c, mcux_lpi2c_driver_api) = {
 	IF_ENABLED(DT_INST_IRQ_HAS_IDX(n, 0),				\
 		(I2C_MCUX_LPI2C_MODULE_IRQ_CONNECT(n)))
 
+#ifdef CONFIG_NXP_LP_FLEXCOMM
+#define PARENT_DEV(n)							\
+	.parent_dev = DEVICE_DT_GET(DT_INST_PARENT(n)),
+#else
+#define PARENT_DEV(n)
+#endif /* CONFIG_NXP_LP_FLEXCOMM */
+
 #define I2C_MCUX_LPI2C_INIT(n)						\
 	PINCTRL_DT_INST_DEFINE(n);					\
 									\
@@ -370,6 +391,7 @@ static DEVICE_API(i2c, mcux_lpi2c_driver_api) = {
 									\
 	static const struct mcux_lpi2c_config mcux_lpi2c_config_##n = {	\
 		DEVICE_MMIO_NAMED_ROM_INIT(reg_base, DT_DRV_INST(n)),	\
+		PARENT_DEV(n)						\
 		.clock_dev = DEVICE_DT_GET(DT_INST_CLOCKS_CTLR(n)),	\
 		.clock_subsys =						\
 			(clock_control_subsys_t)DT_INST_CLOCKS_CELL(n, name),\