diff --git a/modules/Kconfig.nordic b/modules/Kconfig.nordic
index 4f268bc8251..bef8b1d2f6c 100644
--- a/modules/Kconfig.nordic
+++ b/modules/Kconfig.nordic
@@ -11,6 +11,7 @@ menuconfig NRF_802154_RADIO_DRIVER
 	bool "Enable nRF IEEE 802.15.4 radio driver"
 	depends on HAS_HW_NRF_RADIO_IEEE802154
 	select DYNAMIC_INTERRUPTS
+	select ENTROPY_GENERATOR
 	help
 	  This option enables nRF IEEE 802.15.4 radio driver in Zephyr. Note,
 	  that beside the radio peripheral itself, this drivers occupies several
diff --git a/samples/boards/nrf/ieee802154/802154_rpmsg/CMakeLists.txt b/samples/boards/nrf/ieee802154/802154_rpmsg/CMakeLists.txt
new file mode 100644
index 00000000000..6e3bbd49d66
--- /dev/null
+++ b/samples/boards/nrf/ieee802154/802154_rpmsg/CMakeLists.txt
@@ -0,0 +1,8 @@
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.13.1)
+
+find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
+project(802154_rpmsg)
+
+target_sources(app PRIVATE src/main.c)
diff --git a/samples/boards/nrf/ieee802154/802154_rpmsg/README.rst b/samples/boards/nrf/ieee802154/802154_rpmsg/README.rst
new file mode 100644
index 00000000000..aab3a6b2496
--- /dev/null
+++ b/samples/boards/nrf/ieee802154/802154_rpmsg/README.rst
@@ -0,0 +1,32 @@
+.. _nrf-ieee802154-rpmsg-sample:
+
+nRF IEEE 802.15.4: Serialization RPMsg
+######################################
+
+Overview
+********
+
+This sample exposes IEEE 802.15.4 radio driver support
+to another device or CPU using the RPMsg transport which is
+a part of `OpenAMP <https://github.com/OpenAMP/open-amp/>`__.
+
+Requirements
+************
+
+* A board with nRF53 SoC
+
+Building and Running
+********************
+
+This sample can be found under :zephyr_file:`samples/boards/nrf/ieee802154/802154_rpmsg`
+in the Zephyr tree.
+
+To use this application, you need a board with nRF53 SoC.
+You can then build this application and flash it onto your board in
+the usual way. See :ref:`boards` for board-specific building and
+programming information.
+
+To test this sample, you need a separate device/CPU that acts as 802.15.4
+serialization RPMsg peer.
+This sample is compatible with the Nordic 802.15.4 serialization. See the
+:option:`CONFIG_NRF_802154_SER_HOST` configuration option for more information.
diff --git a/samples/boards/nrf/ieee802154/802154_rpmsg/prj.conf b/samples/boards/nrf/ieee802154/802154_rpmsg/prj.conf
new file mode 100644
index 00000000000..192208531c4
--- /dev/null
+++ b/samples/boards/nrf/ieee802154/802154_rpmsg/prj.conf
@@ -0,0 +1,6 @@
+CONFIG_OPENAMP=y
+CONFIG_OPENAMP_MASTER=n
+CONFIG_OPENAMP_SLAVE=y
+
+CONFIG_NRF_802154_SER_RADIO=y
+CONFIG_NRF_802154_SL_OPENSOURCE=y
diff --git a/samples/boards/nrf/ieee802154/802154_rpmsg/sample.yaml b/samples/boards/nrf/ieee802154/802154_rpmsg/sample.yaml
new file mode 100644
index 00000000000..4a1b65e6db4
--- /dev/null
+++ b/samples/boards/nrf/ieee802154/802154_rpmsg/sample.yaml
@@ -0,0 +1,4 @@
+sample:
+  description: Allows Zephyr to provide 802.15.4 connectivity
+    for nRF devices via RPMsg.
+  name: 802.15.4 RPMsg serialization
diff --git a/samples/boards/nrf/ieee802154/802154_rpmsg/src/main.c b/samples/boards/nrf/ieee802154/802154_rpmsg/src/main.c
new file mode 100644
index 00000000000..7a8db0e6111
--- /dev/null
+++ b/samples/boards/nrf/ieee802154/802154_rpmsg/src/main.c
@@ -0,0 +1,16 @@
+/*
+ * Copyright (c) 2020 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <sys/__assert.h>
+#include <zephyr.h>
+
+#include <nrf_802154_serialization_error.h>
+
+void nrf_802154_serialization_error(const nrf_802154_ser_err_data_t *err)
+{
+	(void)err;
+	__ASSERT(false, "802.15.4 serialization error");
+}