diff --git a/subsys/debug/mipi_stp_decoder.c b/subsys/debug/mipi_stp_decoder.c
index 39aacbdd4d7..4f320a75526 100644
--- a/subsys/debug/mipi_stp_decoder.c
+++ b/subsys/debug/mipi_stp_decoder.c
@@ -6,7 +6,9 @@
 #include <zephyr/debug/mipi_stp_decoder.h>
 #include <string.h>
 
-#if defined(CONFIG_CPU_CORTEX_M) && !defined(CONFIG_CPU_CORTEX_M0)
+#if defined(CONFIG_CPU_CORTEX_M) && \
+	!defined(CONFIG_CPU_CORTEX_M0) && \
+	!defined(CONFIG_CPU_CORTEX_M0PLUS)
 #define UNALIGNED_ACCESS_SUPPORTED 1
 #else
 #define UNALIGNED_ACCESS_SUPPORTED 0