diff --git a/dts/arm/nuvoton/npcx.dtsi b/dts/arm/nuvoton/npcx.dtsi
index 19598e09baf..38369308a18 100644
--- a/dts/arm/nuvoton/npcx.dtsi
+++ b/dts/arm/nuvoton/npcx.dtsi
@@ -52,6 +52,14 @@
 		status = "okay";
 	};
 
+	/* Dummy node of IOs that have leakage current. The user can override
+	 * 'leak-gpios' prop. at board DT file to save more power consumption.
+	 */
+	power_leakage_io: power-leakage-io {
+		compatible = "nuvoton,npcx-leakage-io";
+		status = "okay";
+	};
+
 	soc {
 		bbram: bb-ram@400af000 {
 			compatible = "nuvoton,npcx-bbram";
diff --git a/dts/bindings/pinctrl/nuvoton,npcx-leakage-io.yaml b/dts/bindings/pinctrl/nuvoton,npcx-leakage-io.yaml
new file mode 100644
index 00000000000..f16f6083d18
--- /dev/null
+++ b/dts/bindings/pinctrl/nuvoton,npcx-leakage-io.yaml
@@ -0,0 +1,16 @@
+# Copyright (c) 2022 Nuvoton Technology Corporation.
+# SPDX-License-Identifier: Apache-2.0
+
+description: Nuvoton, NPCX power leakage IOs
+
+compatible: "nuvoton,npcx-leakage-io"
+
+include: [base.yaml]
+
+properties:
+  leak-gpios:
+    type: phandle-array
+    required: false
+    description: |
+      Array of IOs that have leakage current. The user can overwrite this
+      property at the board level DT file to save more power consumption.
diff --git a/soc/arm/nuvoton_npcx/common/power.c b/soc/arm/nuvoton_npcx/common/power.c
index 94363560669..0ab072b4a7b 100644
--- a/soc/arm/nuvoton_npcx/common/power.c
+++ b/soc/arm/nuvoton_npcx/common/power.c
@@ -47,10 +47,12 @@
 
 #include <zephyr/arch/arm/aarch32/cortex_m/cmsis.h>
 #include <zephyr/zephyr.h>
+#include <zephyr/drivers/gpio.h>
 #include <zephyr/drivers/espi.h>
 #include <zephyr/pm/pm.h>
 #include <soc.h>
 
+#include "soc_gpio.h"
 #include "soc_host.h"
 #include "soc_power.h"
 
@@ -84,6 +86,57 @@ enum {
 	NPCX_STANDARD_WAKE_UP,
 };
 
+#define NODE_LEAKAGE_IO DT_INST(0, nuvoton_npcx_leakage_io)
+#if DT_NODE_HAS_PROP(NODE_LEAKAGE_IO, leak_gpios)
+struct npcx_leak_gpio {
+	const struct device *gpio;
+	gpio_pin_t pin;
+};
+
+#define NPCX_POWER_LEAKAGE_IO_INIT(node_id, prop, idx)	{		\
+	.gpio = DEVICE_DT_GET(DT_GPIO_CTLR_BY_IDX(node_id, prop, idx)),	\
+	.pin = DT_GPIO_PIN_BY_IDX(node_id, prop, idx),			\
+},
+
+/*
+ * Get io array which have leakage current from 'leak-gpios' property of
+ * 'power_leakage_io' DT node. User can overwrite this prop. at board DT file to
+ * save power consumption when ec enter deep sleep.
+ *
+ * &power_leakage_io {
+ *       leak-gpios = <&gpio0 0 0
+ *                    &gpiob 1 0>;
+ * };
+ */
+static struct npcx_leak_gpio leak_gpios[] = {
+	DT_FOREACH_PROP_ELEM(NODE_LEAKAGE_IO, leak_gpios, NPCX_POWER_LEAKAGE_IO_INIT)
+};
+
+static void npcx_power_suspend_leak_io_pads(void)
+{
+	for (int i = 0; i < ARRAY_SIZE(leak_gpios); i++) {
+		npcx_gpio_disable_io_pads(leak_gpios[i].gpio, leak_gpios[i].pin);
+	}
+}
+
+static void npcx_power_restore_leak_io_pads(void)
+{
+	for (int i = 0; i < ARRAY_SIZE(leak_gpios); i++) {
+		npcx_gpio_enable_io_pads(leak_gpios[i].gpio, leak_gpios[i].pin);
+	}
+}
+#else
+void npcx_power_suspend_leak_io_pads(void)
+{
+	/* do nothing */
+}
+
+void npcx_power_restore_leak_io_pads(void)
+{
+	/* do nothing */
+}
+#endif /* DT_NODE_HAS_PROP(NODE_LEAKAGE_IO, leak_gpios) */
+
 static void npcx_power_enter_system_sleep(int slp_mode, int wk_mode)
 {
 	/* Disable interrupts */
@@ -99,6 +152,12 @@ static void npcx_power_enter_system_sleep(int slp_mode, int wk_mode)
 	npcx_clock_control_turn_on_system_sleep(slp_mode == NPCX_DEEP_SLEEP,
 					wk_mode == NPCX_INSTANT_WAKE_UP);
 
+	/*
+	 * Disable the connection between io pads that have leakage current and
+	 * input buffer to save power consumption.
+	 */
+	npcx_power_suspend_leak_io_pads();
+
 	/* Turn on eSPI/LPC host access wake-up interrupt. */
 	if (IS_ENABLED(CONFIG_ESPI_NPCX)) {
 		npcx_host_enable_access_interrupt();
@@ -129,6 +188,12 @@ static void npcx_power_enter_system_sleep(int slp_mode, int wk_mode)
 		npcx_host_disable_access_interrupt();
 	}
 
+	/*
+	 * Restore the connection between io pads that have leakage current and
+	 * input buffer.
+	 */
+	npcx_power_restore_leak_io_pads();
+
 	/* Turn off system sleep mode. */
 	npcx_clock_control_turn_off_system_sleep();
 }