diff --git a/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840.dts b/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840.dts
index 21b73dd43dc..01a756e7301 100644
--- a/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840.dts
+++ b/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840.dts
@@ -115,6 +115,14 @@
 			<5 &adc 7>;    /* A5 = P0.31 = AIN7 */
 	};
 
+	nrf_radio_fem: fem {
+		compatible = "generic-fem-two-ctrl-pins";
+		ctx-gpios = <&gpio1 5 0>;
+		ctx-settle-time-us = <5>;
+		crx-gpios = <&gpio1 6 0>;
+		crx-settle-time-us = <5>;
+	};
+
 	/* These aliases are provided for compatibility with samples */
 	aliases {
 		led0 = &led0;
@@ -130,6 +138,10 @@
 	};
 };
 
+&radio {
+	fem = <&nrf_radio_fem>;
+};
+
 &adc {
 	status = "okay";
 };
diff --git a/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840_defconfig b/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840_defconfig
index ffd7ced78b4..624a2a73295 100644
--- a/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840_defconfig
+++ b/boards/arm/ubx_bmd345eval_nrf52840/ubx_bmd345eval_nrf52840_defconfig
@@ -28,11 +28,3 @@ CONFIG_UART_CONSOLE=y
 
 # additional board options
 CONFIG_GPIO_AS_PINRESET=y
-
-# PA GPIO Pin
-CONFIG_BT_CTLR_GPIO_PA=y
-CONFIG_BT_CTLR_GPIO_PA_PIN=37
-
-# LNA GPIO Pin
-CONFIG_BT_CTLR_GPIO_LNA=y
-CONFIG_BT_CTLR_GPIO_LNA_PIN=38
diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio.c b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio.c
index 4c69032dbdf..f78fbe5cecf 100644
--- a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio.c
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio.c
@@ -7,6 +7,8 @@
 
 #include <sys/dlist.h>
 #include <toolchain.h>
+#include <dt-bindings/gpio/gpio.h>
+#include <soc.h>
 
 #include <hal/nrf_rtc.h>
 #include <hal/nrf_timer.h>
@@ -23,46 +25,102 @@
 
 #include "radio_internal.h"
 
+/* Converts the GPIO controller in a FEM property's GPIO specification
+ * to its nRF register map pointer.
+ *
+ * Make sure to use NRF_DT_CHECK_GPIO_CTLR_IS_SOC to check the GPIO
+ * controller has the right compatible wherever you use this.
+ */
+#define NRF_FEM_GPIO(prop) \
+	((NRF_GPIO_Type *)DT_REG_ADDR(DT_GPIO_CTLR(FEM_NODE, prop)))
+
+/* Converts GPIO specification to a PSEL value. */
+#define NRF_FEM_PSEL(prop) NRF_DT_GPIOS_TO_PSEL(FEM_NODE, prop)
+
+/* Check if GPIO flags are active low. */
+#define ACTIVE_LOW(flags) ((flags) & GPIO_ACTIVE_LOW)
+
+/* Check if GPIO flags contain unsupported values. */
+#define BAD_FLAGS(flags) ((flags) & ~GPIO_ACTIVE_LOW)
+
+/* GPIOTE OUTINIT setting for a pin's inactive level, from its
+ * devicetree flags.
+ */
+#define OUTINIT_INACTIVE(flags)			\
+	(ACTIVE_LOW(flags) ?				\
+	 GPIOTE_CONFIG_OUTINIT_High :			\
+	 GPIOTE_CONFIG_OUTINIT_Low)
+
+#if defined(FEM_NODE)
+BUILD_ASSERT(!HAL_RADIO_GPIO_PA_OFFSET_MISSING,
+	     "fem node " DT_NODE_PATH(FEM_NODE) " has property "
+	     HAL_RADIO_GPIO_PA_PROP_NAME " set, so you must also set "
+	     HAL_RADIO_GPIO_PA_OFFSET_PROP_NAME);
+
+BUILD_ASSERT(!HAL_RADIO_GPIO_LNA_OFFSET_MISSING,
+	     "fem node " DT_NODE_PATH(FEM_NODE) " has property "
+	     HAL_RADIO_GPIO_LNA_PROP_NAME " set, so you must also set "
+	     HAL_RADIO_GPIO_LNA_OFFSET_PROP_NAME);
+#endif	/* FEM_NODE */
+
+/*
+ * "Manual" conversions of devicetree values to register bits. We
+ * can't use the Zephyr GPIO API here, so we need this extra
+ * boilerplate.
+ */
+
 #if defined(HAL_RADIO_GPIO_HAVE_PA_PIN)
-#if ((CONFIG_BT_CTLR_GPIO_PA_PIN) > 31)
-#define NRF_GPIO_PA     NRF_P1
-#define NRF_GPIO_PA_PIN ((CONFIG_BT_CTLR_GPIO_PA_PIN) - 32)
-#else
-#define NRF_GPIO_PA     NRF_P0
-#define NRF_GPIO_PA_PIN CONFIG_BT_CTLR_GPIO_PA_PIN
-#endif
+#define NRF_GPIO_PA       NRF_FEM_GPIO(HAL_RADIO_GPIO_PA_PROP)
+#define NRF_GPIO_PA_PIN   DT_GPIO_PIN(FEM_NODE, HAL_RADIO_GPIO_PA_PROP)
+#define NRF_GPIO_PA_FLAGS DT_GPIO_FLAGS(FEM_NODE, HAL_RADIO_GPIO_PA_PROP)
+#define NRF_GPIO_PA_PSEL  NRF_FEM_PSEL(HAL_RADIO_GPIO_PA_PROP)
+NRF_DT_CHECK_GPIO_CTLR_IS_SOC(FEM_NODE, HAL_RADIO_GPIO_PA_PROP,
+			      HAL_RADIO_GPIO_PA_PROP_NAME);
+BUILD_ASSERT(!BAD_FLAGS(NRF_GPIO_PA_FLAGS),
+	     "fem node " DT_NODE_PATH(FEM_NODE) " has invalid GPIO flags in "
+	     HAL_RADIO_GPIO_PA_PROP_NAME
+	     "; only GPIO_ACTIVE_LOW or GPIO_ACTIVE_HIGH are supported");
 #endif /* HAL_RADIO_GPIO_HAVE_PA_PIN */
 
 #if defined(HAL_RADIO_GPIO_HAVE_LNA_PIN)
-#if ((CONFIG_BT_CTLR_GPIO_LNA_PIN) > 31)
-#define NRF_GPIO_LNA     NRF_P1
-#define NRF_GPIO_LNA_PIN ((CONFIG_BT_CTLR_GPIO_LNA_PIN) - 32)
-#else
-#define NRF_GPIO_LNA     NRF_P0
-#define NRF_GPIO_LNA_PIN CONFIG_BT_CTLR_GPIO_LNA_PIN
-#endif
+#define NRF_GPIO_LNA       NRF_FEM_GPIO(HAL_RADIO_GPIO_LNA_PROP)
+#define NRF_GPIO_LNA_PIN   DT_GPIO_PIN(FEM_NODE, HAL_RADIO_GPIO_LNA_PROP)
+#define NRF_GPIO_LNA_FLAGS DT_GPIO_FLAGS(FEM_NODE, HAL_RADIO_GPIO_LNA_PROP)
+#define NRF_GPIO_LNA_PSEL  NRF_FEM_PSEL(HAL_RADIO_GPIO_LNA_PROP)
+NRF_DT_CHECK_GPIO_CTLR_IS_SOC(FEM_NODE, HAL_RADIO_GPIO_LNA_PROP,
+			      HAL_RADIO_GPIO_LNA_PROP_NAME);
+BUILD_ASSERT(!BAD_FLAGS(NRF_GPIO_LNA_FLAGS),
+	     "fem node " DT_NODE_PATH(FEM_NODE) " has invalid GPIO flags in "
+	     HAL_RADIO_GPIO_LNA_PROP_NAME
+	     "; only GPIO_ACTIVE_LOW or GPIO_ACTIVE_HIGH are supported");
 #endif /* HAL_RADIO_GPIO_HAVE_LNA_PIN */
 
-#if defined(CONFIG_BT_CTLR_GPIO_PDN_PIN)
-#if ((CONFIG_BT_CTLR_GPIO_PDN_PIN) > 31)
-#define NRF_GPIO_PDN     NRF_P1
-#define NRF_GPIO_PDN_PIN ((CONFIG_BT_CTLR_GPIO_PDN_PIN) - 32)
-#else
-#define NRF_GPIO_PDN     NRF_P0
-#define NRF_GPIO_PDN_PIN CONFIG_BT_CTLR_GPIO_PDN_PIN
-#endif
-#endif /* CONFIG_BT_CTLR_GPIO_PDN_PIN */
+#if defined(HAL_RADIO_FEM_IS_NRF21540)
 
-#if defined(CONFIG_BT_CTLR_GPIO_CSN_PIN)
-#if ((CONFIG_BT_CTLR_GPIO_CSN_PIN) > 31)
-#define NRF_GPIO_CSN     NRF_P1
-#define NRF_GPIO_CSN_PIN ((CONFIG_BT_CTLR_GPIO_CSN_PIN) - 32)
-#else
-#define NRF_GPIO_CSN     NRF_P0
-#define NRF_GPIO_CSN_PIN CONFIG_BT_CTLR_GPIO_CSN_PIN
-#endif
-#endif /* CONFIG_BT_CTLR_GPIO_CSN_PIN */
+#if DT_NODE_HAS_PROP(FEM_NODE, pdn_gpios)
+#define NRF_GPIO_PDN        NRF_FEM_GPIO(pdn_gpios)
+#define NRF_GPIO_PDN_PIN    DT_GPIO_PIN(FEM_NODE, pdn_gpios)
+#define NRF_GPIO_PDN_FLAGS  DT_GPIO_FLAGS(FEM_NODE, pdn_gpios)
+#define NRF_GPIO_PDN_PSEL   NRF_FEM_PSEL(pdn_gpios)
+#define NRF_GPIO_PDN_OFFSET DT_PROP(FEM_NODE, pdn_settle_time_us)
+NRF_DT_CHECK_GPIO_CTLR_IS_SOC(FEM_NODE, pdn_gpios, "pdn-gpios");
+#endif	/* DT_NODE_HAS_PROP(FEM_NODE, pdn_gpios) */
 
+/* CSN is special because it comes from the spi-if property. */
+#if defined(HAL_RADIO_FEM_NRF21540_HAS_CSN)
+#define NRF_GPIO_CSN_CTLR  DT_SPI_DEV_CS_GPIOS_CTLR(FEM_SPI_DEV_NODE)
+#define NRF_GPIO_CSN       ((NRF_GPIO_Type *)DT_REG_ADDR(NRF_GPIO_CSN_CTLR))
+#define NRF_GPIO_CSN_PIN   DT_SPI_DEV_CS_GPIOS_PIN(FEM_SPI_DEV_NODE)
+#define NRF_GPIO_CSN_FLAGS DT_SPI_DEV_CS_GPIOS_FLAGS(FEM_SPI_DEV_NODE)
+#define NRF_GPIO_CSN_PSEL  (NRF_GPIO_CSN_PIN + \
+			    (DT_PROP(NRF_GPIO_CSN_CTLR, port) << 5))
+BUILD_ASSERT(DT_NODE_HAS_COMPAT(NRF_GPIO_CSN_CTLR, nordic_nrf_gpio),
+	     "fem node " DT_NODE_PATH(FEM_NODE) " has a spi-if property, "
+	     " but the chip select pin is not on the SoC. Check cs-gpios in "
+	     DT_NODE_PATH(DT_BUS(FEM_SPI_DEV_NODE)));
+#endif	/* HAL_RADIO_FEM_NRF21540_HAS_CSN */
+
+#endif	/* HAL_RADIO_FEM_IS_NRF21540 */
 
 /* The following two constants are used in nrfx_glue.h for marking these PPI
  * channels and groups as occupied and thus unavailable to other modules.
@@ -107,11 +165,11 @@ void radio_setup(void)
 {
 #if defined(HAL_RADIO_GPIO_HAVE_PA_PIN)
 	NRF_GPIO_PA->DIRSET = BIT(NRF_GPIO_PA_PIN);
-#if defined(HAL_RADIO_GPIO_PA_POL_INV)
-	NRF_GPIO_PA->OUTSET = BIT(NRF_GPIO_PA_PIN);
-#else
-	NRF_GPIO_PA->OUTCLR = BIT(NRF_GPIO_PA_PIN);
-#endif
+	if (ACTIVE_LOW(NRF_GPIO_PA_FLAGS)) {
+		NRF_GPIO_PA->OUTSET = BIT(NRF_GPIO_PA_PIN);
+	} else {
+		NRF_GPIO_PA->OUTCLR = BIT(NRF_GPIO_PA_PIN);
+	}
 #endif /* HAL_RADIO_GPIO_HAVE_PA_PIN */
 
 #if defined(HAL_RADIO_GPIO_HAVE_LNA_PIN)
@@ -120,23 +178,23 @@ void radio_setup(void)
 	radio_gpio_lna_off();
 #endif /* HAL_RADIO_GPIO_HAVE_LNA_PIN */
 
-#if defined(CONFIG_BT_CTLR_GPIO_PDN_PIN)
+#if defined(NRF_GPIO_PDN_PIN)
 	NRF_GPIO_PDN->DIRSET = BIT(NRF_GPIO_PDN_PIN);
-#if defined(HAL_RADIO_GPIO_NRF21540_PDN_POL_INV)
-	NRF_GPIO_PDN->OUTSET = BIT(NRF_GPIO_PDN_PIN);
-#else
-	NRF_GPIO_PDN->OUTCLR = BIT(NRF_GPIO_PDN_PIN);
-#endif
-#endif /* CONFIG_BT_CTLR_GPIO_PDN_PIN */
+	if (ACTIVE_LOW(NRF_GPIO_PDN_FLAGS)) {
+		NRF_GPIO_PDN->OUTSET = BIT(NRF_GPIO_PDN_PIN);
+	} else {
+		NRF_GPIO_PDN->OUTCLR = BIT(NRF_GPIO_PDN_PIN);
+	}
+#endif /* NRF_GPIO_PDN_PIN */
 
-#if defined(CONFIG_BT_CTLR_GPIO_CSN_PIN)
+#if defined(NRF_GPIO_CSN_PIN)
 	NRF_GPIO_CSN->DIRSET = BIT(NRF_GPIO_CSN_PIN);
-#if defined(HAL_RADIO_GPIO_NRF21540_CSN_POL_INV)
-	NRF_GPIO_CSN->OUTSET = BIT(NRF_GPIO_CSN_PIN);
-#else
-	NRF_GPIO_CSN->OUTCLR = BIT(NRF_GPIO_CSN_PIN);
-#endif
-#endif /* CONFIG_BT_CTLR_GPIO_CSN_PIN */
+	if (ACTIVE_LOW(NRF_GPIO_CSN_FLAGS)) {
+		NRF_GPIO_CSN->OUTSET = BIT(NRF_GPIO_CSN_PIN);
+	} else {
+		NRF_GPIO_CSN->OUTCLR = BIT(NRF_GPIO_CSN_PIN);
+	}
+#endif /* NRF_GPIO_CSN_PIN */
 
 	hal_radio_ram_prio_setup();
 }
@@ -1125,24 +1183,15 @@ uint32_t radio_tmr_sample_get(void)
 #if defined(HAL_RADIO_GPIO_HAVE_PA_PIN)
 void radio_gpio_pa_setup(void)
 {
-	/* NOTE: With GPIO Pins above 31, left shift of
-	 *       CONFIG_BT_CTLR_GPIO_PA_PIN by GPIOTE_CONFIG_PSEL_Pos will
-	 *       set the NRF_GPIOTE->CONFIG[n].PORT to 1 (P1 port).
-	 */
 	NRF_GPIOTE->CONFIG[HAL_PALNA_GPIOTE_CHAN] =
 		(GPIOTE_CONFIG_MODE_Task <<
 		 GPIOTE_CONFIG_MODE_Pos) |
-		(CONFIG_BT_CTLR_GPIO_PA_PIN <<
+		(NRF_GPIO_PA_PSEL <<
 		 GPIOTE_CONFIG_PSEL_Pos) |
 		(GPIOTE_CONFIG_POLARITY_Toggle <<
 		 GPIOTE_CONFIG_POLARITY_Pos) |
-#if defined(HAL_RADIO_GPIO_PA_POL_INV)
-		(GPIOTE_CONFIG_OUTINIT_High <<
+		(OUTINIT_INACTIVE(NRF_GPIO_PA_FLAGS) <<
 		 GPIOTE_CONFIG_OUTINIT_Pos);
-#else
-		(GPIOTE_CONFIG_OUTINIT_Low <<
-		 GPIOTE_CONFIG_OUTINIT_Pos);
-#endif
 
 #if defined(HAL_RADIO_FEM_IS_NRF21540)
 	hal_pa_ppi_setup();
@@ -1155,24 +1204,15 @@ void radio_gpio_pa_setup(void)
 #if defined(HAL_RADIO_GPIO_HAVE_LNA_PIN)
 void radio_gpio_lna_setup(void)
 {
-	/* NOTE: With GPIO Pins above 31, left shift of
-	 *       CONFIG_BT_CTLR_GPIO_LNA_PIN by GPIOTE_CONFIG_PSEL_Pos will
-	 *       set the NRF_GPIOTE->CONFIG[n].PORT to 1 (P1 port).
-	 */
 	NRF_GPIOTE->CONFIG[HAL_PALNA_GPIOTE_CHAN] =
 		(GPIOTE_CONFIG_MODE_Task <<
 		 GPIOTE_CONFIG_MODE_Pos) |
-		(CONFIG_BT_CTLR_GPIO_LNA_PIN <<
+		(NRF_GPIO_LNA_PSEL <<
 		 GPIOTE_CONFIG_PSEL_Pos) |
 		(GPIOTE_CONFIG_POLARITY_Toggle <<
 		 GPIOTE_CONFIG_POLARITY_Pos) |
-#if defined(HAL_RADIO_GPIO_LNA_POL_INV)
-		(GPIOTE_CONFIG_OUTINIT_High <<
+		(OUTINIT_INACTIVE(NRF_GPIO_LNA_FLAGS) <<
 		 GPIOTE_CONFIG_OUTINIT_Pos);
-#else
-		(GPIOTE_CONFIG_OUTINIT_Low <<
-		 GPIOTE_CONFIG_OUTINIT_Pos);
-#endif
 
 #if defined(HAL_RADIO_FEM_IS_NRF21540)
 	hal_lna_ppi_setup();
@@ -1181,79 +1221,62 @@ void radio_gpio_lna_setup(void)
 #endif
 }
 
-#if defined(CONFIG_BT_CTLR_GPIO_PDN_PIN)
 void radio_gpio_pdn_setup(void)
 {
-	/* NOTE: With GPIO Pins above 31, left shift of
-	 *       CONFIG_BT_CTLR_GPIO_PA_PIN by GPIOTE_CONFIG_PSEL_Pos will
-	 *       set the NRF_GPIOTE->CONFIG[n].PORT to 1 (P1 port).
-	 */
+	/* Note: the pdn-gpios property is optional. */
+#if defined(NRF_GPIO_PDN)
 	NRF_GPIOTE->CONFIG[HAL_PDN_GPIOTE_CHAN] =
 		(GPIOTE_CONFIG_MODE_Task <<
 		 GPIOTE_CONFIG_MODE_Pos) |
-		(CONFIG_BT_CTLR_GPIO_PDN_PIN <<
+		(NRF_GPIO_PDN_PSEL <<
 		 GPIOTE_CONFIG_PSEL_Pos) |
 		(GPIOTE_CONFIG_POLARITY_Toggle <<
 		 GPIOTE_CONFIG_POLARITY_Pos) |
-#if defined(HAL_RADIO_GPIO_NRF21540_PDN_POL_INV)
-		(GPIOTE_CONFIG_OUTINIT_High <<
+		(OUTINIT_INACTIVE(NRF_GPIO_PDN_FLAGS) <<
 		 GPIOTE_CONFIG_OUTINIT_Pos);
-#else
-		(GPIOTE_CONFIG_OUTINIT_Low <<
-		 GPIOTE_CONFIG_OUTINIT_Pos);
-#endif
+#endif /* NRF_GPIO_PDN_PIN */
 }
-#endif /* CONFIG_BT_CTLR_GPIO_PDN_PIN */
 
-#if defined(CONFIG_BT_CTLR_GPIO_CSN_PIN)
 void radio_gpio_csn_setup(void)
 {
-	/* NOTE: With GPIO Pins above 31, left shift of
-	 *       CONFIG_BT_CTLR_GPIO_PA_PIN by GPIOTE_CONFIG_PSEL_Pos will
-	 *       set the NRF_GPIOTE->CONFIG[n].PORT to 1 (P1 port).
-	 */
+	/* Note: the spi-if property is optional. */
+#if defined(NRF_GPIO_CSN_PIN)
 	NRF_GPIOTE->CONFIG[HAL_CSN_GPIOTE_CHAN] =
 		(GPIOTE_CONFIG_MODE_Task <<
 		 GPIOTE_CONFIG_MODE_Pos) |
-		(CONFIG_BT_CTLR_GPIO_CSN_PIN <<
+		(NRF_GPIO_CSN_PSEL <<
 		 GPIOTE_CONFIG_PSEL_Pos) |
 		(GPIOTE_CONFIG_POLARITY_Toggle <<
 		 GPIOTE_CONFIG_POLARITY_Pos) |
-#if defined(HAL_RADIO_GPIO_NRF21540_CSN_POL_INV)
-		(GPIOTE_CONFIG_OUTINIT_High <<
+		(OUTINIT_INACTIVE(NRF_GPIO_CSN_FLAGS) <<
 		 GPIOTE_CONFIG_OUTINIT_Pos);
-#else
-		(GPIOTE_CONFIG_OUTINIT_Low <<
-		 GPIOTE_CONFIG_OUTINIT_Pos);
-#endif
+#endif /* NRF_GPIO_CSN_PIN */
 }
-#endif /* CONFIG_BT_CTLR_GPIO_CSN_PIN */
 
 void radio_gpio_lna_on(void)
 {
-#if defined(HAL_RADIO_GPIO_LNA_POL_INV)
-	NRF_GPIO_LNA->OUTCLR = BIT(NRF_GPIO_LNA_PIN);
-#else
-	NRF_GPIO_LNA->OUTSET = BIT(NRF_GPIO_LNA_PIN);
-#endif
+	if (ACTIVE_LOW(NRF_GPIO_LNA_FLAGS)) {
+		NRF_GPIO_LNA->OUTCLR = BIT(NRF_GPIO_LNA_PIN);
+	} else {
+		NRF_GPIO_LNA->OUTSET = BIT(NRF_GPIO_LNA_PIN);
+	}
 }
 
 void radio_gpio_lna_off(void)
 {
-#if defined(HAL_RADIO_GPIO_LNA_POL_INV)
-	NRF_GPIO_LNA->OUTSET = BIT(NRF_GPIO_LNA_PIN);
-#else
-	NRF_GPIO_LNA->OUTCLR = BIT(NRF_GPIO_LNA_PIN);
-#endif
+	if (ACTIVE_LOW(NRF_GPIO_LNA_FLAGS)) {
+		NRF_GPIO_LNA->OUTSET = BIT(NRF_GPIO_LNA_PIN);
+	} else {
+		NRF_GPIO_LNA->OUTCLR = BIT(NRF_GPIO_LNA_PIN);
+	}
 }
 #endif /* HAL_RADIO_GPIO_HAVE_LNA_PIN */
 
 void radio_gpio_pa_lna_enable(uint32_t trx_us)
 {
 	nrf_timer_cc_set(EVENT_TIMER, 2, trx_us);
-#if defined(HAL_RADIO_FEM_IS_NRF21540)
-	nrf_timer_cc_set(EVENT_TIMER, 3, (trx_us -
-					  HAL_RADIO_GPIO_NRF21540_PDN_OFFSET));
+#if defined(HAL_RADIO_FEM_IS_NRF21540) && DT_NODE_HAS_PROP(FEM_NODE, pdn_gpios)
+	nrf_timer_cc_set(EVENT_TIMER, 3, (trx_us - NRF_GPIO_PDN_OFFSET));
 	hal_radio_nrf_ppi_channels_enable(BIT(HAL_ENABLE_PALNA_PPI) |
 					  BIT(HAL_DISABLE_PALNA_PPI) |
 					  BIT(HAL_ENABLE_FEM_PPI) |
diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5.h b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5.h
index 7ff85525838..46fc2a5c981 100644
--- a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5.h
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5.h
@@ -60,39 +60,8 @@
 #define HAL_CSN_GPIOTE_CHAN 2
 #endif
 
-#if defined(CONFIG_BT_CTLR_GPIO_PA)
-#define HAL_RADIO_GPIO_HAVE_PA_PIN 1
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_LNA)
-#define HAL_RADIO_GPIO_HAVE_LNA_PIN 1
-#endif
-
-#if defined(CONFIG_BT_CTLR_GPIO_PA_POL_INV)
-#define HAL_RADIO_GPIO_PA_POL_INV CONFIG_BT_CTLR_GPIO_PA_POL_INV
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_LNA_POL_INV)
-#define HAL_RADIO_GPIO_LNA_POL_INV CONFIG_BT_CTLR_GPIO_LNA_POL_INV
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_PDN_POL_INV)
-#define HAL_RADIO_GPIO_NRF21540_PDN_POL_INV CONFIG_BT_CTLR_GPIO_PDN_POL_INV
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_CSN_POL_INV)
-#define HAL_RADIO_GPIO_NRF21540_CSN_POL_INV CONFIG_BT_CTLR_GPIO_CSN_POL_INV
-#endif
-
-#if defined(CONFIG_BT_CTLR_GPIO_PA_OFFSET)
-#define HAL_RADIO_GPIO_PA_OFFSET CONFIG_BT_CTLR_GPIO_PA_OFFSET
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_LNA_OFFSET)
-#define HAL_RADIO_GPIO_LNA_OFFSET CONFIG_BT_CTLR_GPIO_LNA_OFFSET
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_PDN_CSN_OFFSET)
-#define HAL_RADIO_GPIO_NRF21540_PDN_OFFSET CONFIG_BT_CTLR_GPIO_PDN_CSN_OFFSET
-#endif
-
-#if defined(CONFIG_BT_CTLR_FEM_NRF21540)
-#define HAL_RADIO_FEM_IS_NRF21540 1
-#endif
+/* This has to come before the ppi/dppi includes below. */
+#include "radio_nrf5_fem.h"
 
 #if defined(PPI_PRESENT)
 #include "radio_nrf5_ppi.h"
diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem.h b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem.h
new file mode 100644
index 00000000000..7d419c1b374
--- /dev/null
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem.h
@@ -0,0 +1,60 @@
+/*
+ * Copyright (c) 2021 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Generic helper macros for getting radio front-end module (FEM)
+ * settings from devicetree. The main task here is to check the
+ * devicetree compatible of the node the fem property points at, and
+ * pull in a subheader that translates from that compatible's specific
+ * properties to the generic macros required by the nRF5 radio HAL.
+ */
+
+#include <devicetree.h>
+#include <dt-bindings/gpio/gpio.h>
+
+#if DT_NODE_HAS_PROP(DT_NODELABEL(radio), fem)
+#define FEM_NODE             DT_PHANDLE(DT_NODELABEL(radio), fem)
+#if DT_NODE_HAS_STATUS(FEM_NODE, okay)
+#define HAL_RADIO_HAVE_FEM
+#endif	/* DT_NODE_HAS_STATUS(FEM_NODE, okay) */
+#endif	/* DT_NODE_HAS_PROP(DT_NODELABEL(radio), fem)) */
+
+/* Does FEM_NODE have a particular DT compatible? */
+#define FEM_HAS_COMPAT(compat) DT_NODE_HAS_COMPAT(FEM_NODE, compat)
+
+/* Does FEM_NODE have a particular DT property defined? */
+#define FEM_HAS_PROP(prop) DT_NODE_HAS_PROP(FEM_NODE, prop)
+
+/*
+ * Device-specific settings are pulled in based FEM_NODE's compatible
+ * property.
+ */
+
+#ifdef HAL_RADIO_HAVE_FEM
+#if FEM_HAS_COMPAT(generic_fem_two_ctrl_pins)
+#include "radio_nrf5_fem_generic.h"
+#elif FEM_HAS_COMPAT(nordic_nrf21540_fem)
+#include "radio_nrf5_fem_nrf21540.h"
+#else
+#error "radio node fem property has an unsupported compatible"
+#endif	/* FEM_HAS_COMPAT(generic_fem_two_ctrl_pins) */
+#endif	/* HAL_RADIO_HAVE_FEM */
+
+/*
+ * Define POL_INV macros expected by radio_nrf5_dppi as needed.
+ */
+
+#ifdef HAL_RADIO_GPIO_HAVE_PA_PIN
+#if DT_GPIO_FLAGS(FEM_NODE, HAL_RADIO_GPIO_PA_PROP) & GPIO_ACTIVE_LOW
+#define HAL_RADIO_GPIO_PA_POL_INV
+#endif
+#endif	/* HAL_RADIO_GPIO_HAVE_PA_PIN */
+
+#ifdef HAL_RADIO_GPIO_HAVE_LNA_PIN
+#if DT_GPIO_FLAGS(FEM_NODE, HAL_RADIO_GPIO_LNA_PROP) & GPIO_ACTIVE_LOW
+#define HAL_RADIO_GPIO_LNA_POL_INV
+#endif
+#endif	/* HAL_RADIO_GPIO_HAVE_LNA_PIN */
diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_generic.h b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_generic.h
new file mode 100644
index 00000000000..f99a73991c9
--- /dev/null
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_generic.h
@@ -0,0 +1,49 @@
+/*
+ * Copyright (c) 2021 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * This file contains helper macros for dealing with the devicetree
+ * radio node's fem property, in the case that it has compatible
+ * "generic-fem-two-ctrl-pins".
+ *
+ * Do not include it directly.
+ *
+ * For these devices:
+ *
+ *  Value             Property
+ *  ---------         --------
+ *  PA pin            ctx-gpios
+ *  PA offset         ctx-settle-time-us
+ *  LNA pin           crx-gpios
+ *  LNA offset        crx-settle-time-us
+ */
+
+#define HAL_RADIO_GPIO_PA_PROP_NAME         "ctx-gpios"
+#define HAL_RADIO_GPIO_PA_OFFSET_PROP_NAME  "ctx-settle-time-us"
+#define HAL_RADIO_GPIO_LNA_PROP_NAME        "crx-gpios"
+#define HAL_RADIO_GPIO_LNA_OFFSET_PROP_NAME "crx-settle-time-us"
+
+#if FEM_HAS_PROP(ctx_gpios)
+#define HAL_RADIO_GPIO_HAVE_PA_PIN         1
+#define HAL_RADIO_GPIO_PA_PROP             ctx_gpios
+
+#define HAL_RADIO_GPIO_PA_OFFSET_MISSING   (!FEM_HAS_PROP(ctx_settle_time_us))
+#define HAL_RADIO_GPIO_PA_OFFSET \
+	DT_PROP_OR(FEM_NODE, ctx_settle_time_us, 0)
+#else  /* !FEM_HAS_PROP(ctx_gpios) */
+#define HAL_RADIO_GPIO_PA_OFFSET_MISSING 0
+#endif	/* FEM_HAS_PROP(ctx_gpios) */
+
+#if FEM_HAS_PROP(crx_gpios)
+#define HAL_RADIO_GPIO_HAVE_LNA_PIN         1
+#define HAL_RADIO_GPIO_LNA_PROP             crx_gpios
+
+#define HAL_RADIO_GPIO_LNA_OFFSET_MISSING   (!FEM_HAS_PROP(crx_settle_time_us))
+#define HAL_RADIO_GPIO_LNA_OFFSET \
+	DT_PROP_OR(FEM_NODE, crx_settle_time_us, 0)
+#else  /* !FEM_HAS_PROP(crx_gpios) */
+#define HAL_RADIO_GPIO_LNA_OFFSET_MISSING 0
+#endif	/* FEM_HAS_PROP(crx_gpios) */
diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_nrf21540.h b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_nrf21540.h
new file mode 100644
index 00000000000..6b473198ffa
--- /dev/null
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/radio/radio_nrf5_fem_nrf21540.h
@@ -0,0 +1,77 @@
+/*
+ * Copyright (c) 2021 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * This file contains helper macros for dealing with the devicetree
+ * radio node's fem property, in the case that it has compatible
+ * "nordic,nrf21540-fem".
+ *
+ * Do not include it directly.
+ *
+ * For nRF21540 devices:
+ *
+ *  Value             Property
+ *  ---------         --------
+ *  PA pin            tx-en-gpios
+ *  PA offset         tx-en-settle-time-us
+ *  LNA pin           rx-en-gpios
+ *  LNA offset        rx-en-settle-time-us
+ *  PDN pin           pdn-gpios
+ *  PDN offset        pdn-settle-time-us
+ *
+ * The spi-if property may point at a SPI device node representing the
+ * FEM's SPI control interface. See the binding for details.
+ */
+
+#define HAL_RADIO_FEM_IS_NRF21540 1
+
+#define HAL_RADIO_GPIO_PA_PROP_NAME         "tx-en-gpios"
+#define HAL_RADIO_GPIO_PA_OFFSET_PROP_NAME  "tx-en-settle-time-us"
+#define HAL_RADIO_GPIO_LNA_PROP_NAME        "rx-en-gpios"
+#define HAL_RADIO_GPIO_LNA_OFFSET_PROP_NAME "rx-en-settle-time-us"
+
+/* This FEM's PA and LNA offset properties have defaults set. */
+#define HAL_RADIO_GPIO_PA_OFFSET_MISSING 0
+#define HAL_RADIO_GPIO_LNA_OFFSET_MISSING 0
+
+#if FEM_HAS_PROP(tx_en_gpios)
+#define HAL_RADIO_GPIO_HAVE_PA_PIN 1
+#define HAL_RADIO_GPIO_PA_PROP     tx_en_gpios
+#define HAL_RADIO_GPIO_PA_OFFSET   DT_PROP(FEM_NODE, tx_en_settle_time_us)
+#endif	/* FEM_HAS_PROP(tx_en_gpios) */
+
+#if FEM_HAS_PROP(rx_en_gpios)
+#define HAL_RADIO_GPIO_HAVE_LNA_PIN 1
+#define HAL_RADIO_GPIO_LNA_PROP     rx_en_gpios
+#define HAL_RADIO_GPIO_LNA_OFFSET   DT_PROP(FEM_NODE, rx_en_settle_time_us)
+#endif	/* FEM_HAS_PROP(rx_en_gpios) */
+
+/*
+ * The POL_INV macros defined below are just to keep things simple in
+ * radio_nrf5_dppi.h, which uses them.
+ */
+
+#if FEM_HAS_PROP(pdn_gpios)
+#if DT_GPIO_FLAGS(FEM_NODE, pdn_gpios) & GPIO_ACTIVE_LOW
+#define HAL_RADIO_GPIO_NRF21540_PDN_POL_INV 1
+#endif	/* DT_GPIO_FLAGS(FEM_NODE, pdn_gpios) & GPIO_ACTIVE_LOW */
+#endif	/* FEM_HAS_PROP(pdn_gpios) */
+
+#if FEM_HAS_PROP(spi_if)
+/* This is the "SPI device" node, i.e. the one with compatible
+ * nordic,nrf21540-fem-spi.
+ */
+#define FEM_SPI_DEV_NODE DT_PHANDLE(FEM_NODE, spi_if)
+/* If the SPI device node has a chip select gpio... */
+#if DT_SPI_DEV_HAS_CS_GPIOS(FEM_SPI_DEV_NODE)
+/* set a macro indicating that, and... */
+#define HAL_RADIO_FEM_NRF21540_HAS_CSN 1
+/* use it to get the CSN polarity. */
+#if DT_SPI_DEV_CS_GPIOS_FLAGS(FEM_SPI_DEV_NODE) & GPIO_ACTIVE_LOW
+#define HAL_RADIO_GPIO_NRF21540_CSN_POL_INV 1
+#endif	/* DT_SPI_DEV_CS_GPIOS_FLAGS(FEM_SPI_DEV_NODE) & GPIO_ACTIVE_LOW */
+#endif	/* DT_SPI_DEV_HAS_CS_GPIOS(FEM_SPI_DEV_NODE) */
+#endif	/* FEM_HAS_PROP(spi_if) */
diff --git a/subsys/bluetooth/controller/ll_sw/openisa/hal/radio_vendor_hal.h b/subsys/bluetooth/controller/ll_sw/openisa/hal/radio_vendor_hal.h
index 267b9c3f7f0..a90aca8fd7b 100644
--- a/subsys/bluetooth/controller/ll_sw/openisa/hal/radio_vendor_hal.h
+++ b/subsys/bluetooth/controller/ll_sw/openisa/hal/radio_vendor_hal.h
@@ -6,16 +6,11 @@
 
 #include "hal/RV32M1/radio/radio.h"
 
-#if defined(CONFIG_BT_CTLR_GPIO_PA)
-#define HAL_RADIO_GPIO_HAVE_PA_PIN
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_LNA)
-#define HAL_RADIO_GPIO_HAVE_LNA_PIN
-#endif
-
-#if defined(CONFIG_BT_CTLR_GPIO_PA_OFFSET)
-#define HAL_RADIO_GPIO_PA_OFFSET CONFIG_BT_CTLR_GPIO_PA_OFFSET
-#endif
-#if defined(CONFIG_BT_CTLR_GPIO_LNA_OFFSET)
-#define HAL_RADIO_GPIO_LNA_OFFSET CONFIG_BT_CTLR_GPIO_LNA_OFFSET
-#endif
+/* The openisa vendor HAL does not have the GPIO support functions
+ * required for handling radio front-end modules with PA/LNAs.
+ *
+ * If these are ever implemented, this file should be updated
+ * appropriately.
+ */
+#undef HAL_RADIO_GPIO_HAVE_PA_PIN
+#undef HAL_RADIO_GPIO_HAVE_LNA_PIN
diff --git a/tests/bluetooth/init/pa_lna.overlay b/tests/bluetooth/init/pa_lna.overlay
new file mode 100644
index 00000000000..5ff670b76e8
--- /dev/null
+++ b/tests/bluetooth/init/pa_lna.overlay
@@ -0,0 +1,13 @@
+/ {
+	nrf_radio_fem: fem {
+		compatible = "generic-fem-two-ctrl-pins";
+		ctx-gpios = <&gpio0 26 0>;
+		ctx-settle-time-us = <5>;
+		crx-gpios = <&gpio0 27 0>;
+		crx-settle-time-us = <5>;
+	};
+};
+
+&radio {
+	fem = <&nrf_radio_fem>;
+};
diff --git a/tests/bluetooth/init/prj_ctlr_4_0.conf b/tests/bluetooth/init/prj_ctlr_4_0.conf
index 016e460e916..3141484dc99 100644
--- a/tests/bluetooth/init/prj_ctlr_4_0.conf
+++ b/tests/bluetooth/init/prj_ctlr_4_0.conf
@@ -24,8 +24,6 @@ CONFIG_BT_CTLR_CONN_RSSI=n
 CONFIG_BT_CTLR_ADV_INDICATION=n
 CONFIG_BT_CTLR_SCAN_REQ_NOTIFY=n
 CONFIG_BT_CTLR_SCAN_REQ_RSSI=n
-CONFIG_BT_CTLR_GPIO_PA=n
-CONFIG_BT_CTLR_GPIO_LNA=n
 CONFIG_BT_CTLR_PROFILE_ISR=n
 CONFIG_BT_CTLR_DEBUG_PINS=n
 CONFIG_BT_HCI_VS_EXT=n
diff --git a/tests/bluetooth/init/prj_ctlr_4_0_dbg.conf b/tests/bluetooth/init/prj_ctlr_4_0_dbg.conf
index 4e3ad65afad..549abd02f23 100644
--- a/tests/bluetooth/init/prj_ctlr_4_0_dbg.conf
+++ b/tests/bluetooth/init/prj_ctlr_4_0_dbg.conf
@@ -26,8 +26,6 @@ CONFIG_BT_CTLR_CONN_RSSI=n
 CONFIG_BT_CTLR_ADV_INDICATION=n
 CONFIG_BT_CTLR_SCAN_REQ_NOTIFY=n
 CONFIG_BT_CTLR_SCAN_REQ_RSSI=n
-CONFIG_BT_CTLR_GPIO_PA=n
-CONFIG_BT_CTLR_GPIO_LNA=n
 CONFIG_BT_CTLR_PROFILE_ISR=n
 CONFIG_BT_CTLR_DEBUG_PINS=n
 CONFIG_BT_HCI_VS_EXT=n
diff --git a/tests/bluetooth/init/prj_ctlr_dbg.conf b/tests/bluetooth/init/prj_ctlr_dbg.conf
index a3e1db67aa0..7eb09931813 100644
--- a/tests/bluetooth/init/prj_ctlr_dbg.conf
+++ b/tests/bluetooth/init/prj_ctlr_dbg.conf
@@ -30,10 +30,6 @@ CONFIG_BT_CTLR_ADV_INDICATION=y
 CONFIG_BT_CTLR_SCAN_REQ_NOTIFY=y
 CONFIG_BT_CTLR_SCAN_REQ_RSSI=y
 CONFIG_BT_CTLR_SCAN_INDICATION=y
-CONFIG_BT_CTLR_GPIO_PA=y
-CONFIG_BT_CTLR_GPIO_PA_PIN=26
-CONFIG_BT_CTLR_GPIO_LNA=y
-CONFIG_BT_CTLR_GPIO_LNA_PIN=27
 CONFIG_BT_CTLR_PROFILE_ISR=y
 CONFIG_BT_CTLR_DEBUG_PINS=y
 CONFIG_BT_CTLR_TEST=y
diff --git a/tests/bluetooth/init/prj_ctlr_tiny.conf b/tests/bluetooth/init/prj_ctlr_tiny.conf
index 6dc864f1351..949f5b5fac7 100644
--- a/tests/bluetooth/init/prj_ctlr_tiny.conf
+++ b/tests/bluetooth/init/prj_ctlr_tiny.conf
@@ -28,8 +28,6 @@ CONFIG_BT_CTLR_ADV_INDICATION=n
 CONFIG_BT_CTLR_SCAN_REQ_NOTIFY=n
 CONFIG_BT_CTLR_SCAN_REQ_RSSI=n
 CONFIG_BT_CTLR_PROFILE_ISR=n
-CONFIG_BT_CTLR_GPIO_PA=n
-CONFIG_BT_CTLR_GPIO_LNA=n
 CONFIG_BT_CTLR_PROFILE_ISR=n
 CONFIG_BT_CTLR_DEBUG_PINS=n
 CONFIG_BT_HCI_VS_EXT=n
diff --git a/tests/bluetooth/init/testcase.yaml b/tests/bluetooth/init/testcase.yaml
index 7840b4832df..e4ee1b085eb 100644
--- a/tests/bluetooth/init/testcase.yaml
+++ b/tests/bluetooth/init/testcase.yaml
@@ -104,7 +104,7 @@ tests:
       - nrf52dk_nrf52832
       - nrf51dk_nrf51422
   bluetooth.init.test_ctlr_dbg:
-    extra_args: CONF_FILE=prj_ctlr_dbg.conf
+    extra_args: CONF_FILE=prj_ctlr_dbg.conf DTC_OVERLAY_FILE=pa_lna.overlay
     platform_allow: nrf52840dk_nrf52840 nrf52dk_nrf52832
       nrf51dk_nrf51422
     integration_platforms: