diff --git a/boards/posix/nrf52_bsim/cmsis_compiler.h b/boards/posix/nrf52_bsim/cmsis_compiler.h
new file mode 100644
index 00000000000..ba634368b13
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+++ b/boards/posix/nrf52_bsim/cmsis_compiler.h
@@ -0,0 +1,36 @@
+/*
+ * Copyright (c) 2023 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/**
+ * This header defines replacements for CMSIS compiler attributes.
+ */
+
+#ifndef BOARDS_POSIX_NRF52_BSIM_CMSIS_COMPILER_H
+#define BOARDS_POSIX_NRF52_BSIM_CMSIS_COMPILER_H
+
+#include <zephyr/toolchain.h>
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+#ifndef __PACKED
+#define __PACKED __packed
+#endif
+
+#ifndef __PACKED_STRUCT
+#define __PACKED_STRUCT struct __packed
+#endif
+
+#ifndef __PACKED_UNION
+#define __PACKED_UNION union __packed
+#endif
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif /* BOARDS_POSIX_NRF52_BSIM_CMSIS_COMPILER_H */