diff --git a/tests/boards/nrf/dmm/src/main.c b/tests/boards/nrf/dmm/src/main.c
index 5ddbebfb838..b21eeb97e02 100644
--- a/tests/boards/nrf/dmm/src/main.c
+++ b/tests/boards/nrf/dmm/src/main.c
@@ -74,7 +74,7 @@ static bool dmm_buffer_in_region_check(struct dmm_test_region *dtr, void *buf, s
 }
 
 static void dmm_check_output_buffer(struct dmm_test_region *dtr, uint32_t *fill_value,
-				    void *data, size_t size, bool was_prealloc)
+				    void *data, size_t size, bool was_prealloc, bool is_cached)
 {
 	void *buf;
 	int retval;
@@ -82,7 +82,9 @@ static void dmm_check_output_buffer(struct dmm_test_region *dtr, uint32_t *fill_
 	memset(data, (*fill_value)++, size);
 	retval = dmm_buffer_out_prepare(dtr->mem_reg, data, size, &buf);
 	zassert_ok(retval);
-	zassert_true(IS_ALIGNED(buf, DMM_DCACHE_LINE_SIZE));
+	if (IS_ENABLED(CONFIG_DCACHE) && is_cached) {
+		zassert_true(IS_ALIGNED(buf, CONFIG_DCACHE_LINE_SIZE));
+	}
 
 	if (IS_ENABLED(CONFIG_HAS_NORDIC_DMM)) {
 		if (was_prealloc) {
@@ -112,7 +114,9 @@ static void dmm_check_input_buffer(struct dmm_test_region *dtr, uint32_t *fill_v
 
 	retval = dmm_buffer_in_prepare(dtr->mem_reg, data, size, &buf);
 	zassert_ok(retval);
-	zassert_true(IS_ALIGNED(buf, DMM_DCACHE_LINE_SIZE));
+	if (IS_ENABLED(CONFIG_DCACHE) && is_cached) {
+		zassert_true(IS_ALIGNED(buf, CONFIG_DCACHE_LINE_SIZE));
+	}
 
 	if (IS_ENABLED(CONFIG_HAS_NORDIC_DMM)) {
 		if (was_prealloc) {
@@ -162,7 +166,7 @@ ZTEST_USER_F(dmm, test_check_dev_cache_out_allocate)
 	uint8_t user_data[16];
 
 	dmm_check_output_buffer(&fixture->regions[DMM_TEST_REGION_CACHE], &fixture->fill_value,
-				user_data, sizeof(user_data), false);
+				user_data, sizeof(user_data), false, true);
 }
 
 ZTEST_USER_F(dmm, test_check_dev_cache_out_preallocate)
@@ -170,7 +174,7 @@ ZTEST_USER_F(dmm, test_check_dev_cache_out_preallocate)
 	static uint8_t user_data[16] DMM_MEMORY_SECTION(DUT_CACHE);
 
 	dmm_check_output_buffer(&fixture->regions[DMM_TEST_REGION_CACHE], &fixture->fill_value,
-				user_data, sizeof(user_data), true);
+				user_data, sizeof(user_data), true, true);
 }
 
 ZTEST_USER_F(dmm, test_check_dev_nocache_in_allocate)
@@ -194,7 +198,7 @@ ZTEST_USER_F(dmm, test_check_dev_nocache_out_allocate)
 	uint8_t user_data[16];
 
 	dmm_check_output_buffer(&fixture->regions[DMM_TEST_REGION_NOCACHE], &fixture->fill_value,
-				user_data, sizeof(user_data), false);
+				user_data, sizeof(user_data), false, false);
 }
 
 ZTEST_USER_F(dmm, test_check_dev_nocache_out_preallocate)
@@ -202,7 +206,7 @@ ZTEST_USER_F(dmm, test_check_dev_nocache_out_preallocate)
 	static uint8_t user_data[16] DMM_MEMORY_SECTION(DUT_NOCACHE);
 
 	dmm_check_output_buffer(&fixture->regions[DMM_TEST_REGION_NOCACHE], &fixture->fill_value,
-				user_data, sizeof(user_data), true);
+				user_data, sizeof(user_data), true, false);
 }
 
 ZTEST_SUITE(dmm, NULL, test_setup, NULL, test_cleanup, NULL);