diff --git a/modules/mbedtls/zephyr_init.c b/modules/mbedtls/zephyr_init.c
index 78602e497e3..bfdc8386346 100644
--- a/modules/mbedtls/zephyr_init.c
+++ b/modules/mbedtls/zephyr_init.c
@@ -94,6 +94,12 @@ static int _mbedtls_init(void)
 	mbedtls_debug_set_threshold(CONFIG_MBEDTLS_DEBUG_LEVEL);
 #endif
 
+#if defined(CONFIG_MBEDTLS_PSA_CRYPTO_CLIENT)
+	if (psa_crypto_init() != PSA_SUCCESS) {
+		return -EIO;
+	}
+#endif
+
 	return 0;
 }