diff --git a/drivers/pwm/pwm_nrfx.c b/drivers/pwm/pwm_nrfx.c
index 373f8eef7e2..52257dce104 100644
--- a/drivers/pwm/pwm_nrfx.c
+++ b/drivers/pwm/pwm_nrfx.c
@@ -15,6 +15,22 @@
 
 LOG_MODULE_REGISTER(pwm_nrfx, CONFIG_PWM_LOG_LEVEL);
 
+/* NRFX_PWM_NRF52_ANOMALY_109_WORKAROUND_ENABLED can be undefined or defined
+ * to 0 or 1, hence the use of #if IS_ENABLED().
+ */
+#if IS_ENABLED(NRFX_PWM_NRF52_ANOMALY_109_WORKAROUND_ENABLED)
+#define ANOMALY_109_IRQ_CONNECT(...) IRQ_CONNECT(__VA_ARGS__)
+#define ANOMALY_109_EGU_IRQ_CONNECT(idx) _EGU_IRQ_CONNECT(idx)
+#define _EGU_IRQ_CONNECT(idx) \
+	extern void nrfx_egu_##idx##_irq_handler(void); \
+	IRQ_CONNECT(DT_IRQN(DT_NODELABEL(egu##idx)), \
+		    DT_IRQ(DT_NODELABEL(egu##idx), priority), \
+		    nrfx_isr, nrfx_egu_##idx##_irq_handler, 0)
+#else
+#define ANOMALY_109_IRQ_CONNECT(...)
+#define ANOMALY_109_EGU_IRQ_CONNECT(idx)
+#endif
+
 #define PWM_NRFX_CH_POLARITY_MASK BIT(15)
 #define PWM_NRFX_CH_COMPARE_MASK  BIT_MASK(15)
 #define PWM_NRFX_CH_VALUE(compare_value, inverted) \
@@ -238,6 +254,8 @@ static int pwm_nrfx_init(const struct device *dev)
 
 	int ret = pinctrl_apply_state(config->pcfg, PINCTRL_STATE_DEFAULT);
 
+	ANOMALY_109_EGU_IRQ_CONNECT(NRFX_PWM_NRF52_ANOMALY_109_EGU_INSTANCE);
+
 	if (ret < 0) {
 		return ret;
 	}
@@ -343,9 +361,16 @@ static int pwm_nrfx_pm_action(const struct device *dev,
 		.seq.length = NRF_PWM_CHANNEL_COUNT,			      \
 		.pcfg = PINCTRL_DT_DEV_CONFIG_GET(PWM(idx)),		      \
 	};								      \
+	static int pwm_nrfx_init##idx(const struct device *dev)		      \
+	{								      \
+		ANOMALY_109_IRQ_CONNECT(				      \
+			DT_IRQN(PWM(idx)), DT_IRQ(PWM(idx), priority),	      \
+			nrfx_isr, nrfx_pwm_##idx##_irq_handler, 0);	      \
+		return pwm_nrfx_init(dev);				      \
+	};								      \
 	PM_DEVICE_DT_DEFINE(PWM(idx), pwm_nrfx_pm_action);		      \
 	DEVICE_DT_DEFINE(PWM(idx),					      \
-			 pwm_nrfx_init, PM_DEVICE_DT_GET(PWM(idx)),	      \
+			 pwm_nrfx_init##idx, PM_DEVICE_DT_GET(PWM(idx)),      \
 			 &pwm_nrfx_##idx##_data,			      \
 			 &pwm_nrfx_##idx##_config,			      \
 			 POST_KERNEL, CONFIG_PWM_INIT_PRIORITY,		      \