diff --git a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/swi.h b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/swi.h
index f576c9361e0..d3963fee7d8 100644
--- a/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/swi.h
+++ b/subsys/bluetooth/controller/ll_sw/nordic/hal/nrf5/swi.h
@@ -18,6 +18,8 @@
 
 #elif defined(CONFIG_SOC_SERIES_NRF53X)
 
+#if defined(CONFIG_BOARD_NRF5340DK_NRF5340_CPUNET)
+
 #define HAL_SWI_RADIO_IRQ  SWI2_IRQn
 #define HAL_SWI_WORKER_IRQ RTC0_IRQn
 
@@ -27,8 +29,23 @@
 #else
 #define HAL_SWI_JOB_IRQ    SWI3_IRQn
 #endif
+
+#elif defined(CONFIG_BOARD_NRF5340PDK_NRF5340_CPUNET)
+
+#define HAL_SWI_RADIO_IRQ  EGU0_IRQn
+#define HAL_SWI_WORKER_IRQ RTC0_IRQn
+
+#if !defined(CONFIG_BT_CTLR_LOW_LAT) && \
+	(CONFIG_BT_CTLR_ULL_HIGH_PRIO == CONFIG_BT_CTLR_ULL_LOW_PRIO)
+#define HAL_SWI_JOB_IRQ    HAL_SWI_WORKER_IRQ
+#else
+#error "Use an unused IRQ line to implement a second SW IRQ."
 #endif
 
+#endif /* CONFIG_BOARD_NRF5340PDK_NRF5340_CPUNET */
+
+#endif /* CONFIG_SOC_SERIES_NRF53X */
+
 static inline void hal_swi_init(void)
 {
 	/* No platform-specific initialization required. */